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LAUNCHING A BIOTECH STARTUP

Some advice for scientists willing to become entrepreneurs, here are six things you should think carefully before embarking on your journey… (OPENING THREAD: some slides I used in a lecture @EU_Commission last month)

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ONCOLOGY FUTURE DIRECTIONS

Here’s a map of some of the most promising research fields in oncology today, plus a video —below— with some advice for scientists willing to become entrepreneurs (from a debate on the future of oncology and how to make it happen)

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CANCER BIOLOGY OPEN PROBLEMS

One of the most important things every investor looks for in a startup is a good problem to solve… Unanswered questions always signal what’s next. Here’s a map of some of the most pressing questions in the oncology field today.

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RNA THERAPIES

RNAs are very active players in cell biology… they carry instructions for making proteins, turn genes on and off, aid chemical reactions, slice and dice other RNAs, and build proteins. Here’s a simple map to understand how can we use them as drugs

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COVID19 VACCINES LANDSCAPE

A different view on phase II – III #COVID_19 vaccines, organized on a spectrum ranging from less innovative technology (older, slower, less uncertain development) to more leading edge approaches (faster, riskier)

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THE ART OF CHOOSING INDICATIONS

You already have a lead candidate for a first specific indication, here’s a simplified conceptual map on how VCs think to choose the most interesting new indications (pipeline strategy).

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INVESTMENTS IN THE TIMES OF #COVID19

Every crisis brings risks and opportunities to the table… here’s a mind map on how SARS-CoV-2 can impact the activities and value chain of the life sciences VC industry

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ORPHAN DRUGS

Most rare diseases still lack approved treatments despite major advances in the knowledge of their molecular basis. Here’s a map of the different therapeutic modalities plus an update on some of the most interesting new developments in each field.

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SARS-CoV-2

The vaccine effort for #COVID19 is unprecedented in scale & speed. To get it right and fast we need new tools and strategies including DNA/RNA vaccines, virus-like particles, T-cell inducing peptides & viral vectors… here’s a map of the leading edge

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Emerging Fields: PROTAC (2)

These protein-slaying drugs can be used to go after targets that drug developers have long considered ‘undruggable’ and may become the next blockbuster therapies… The gold rush is on! here are some areas of research.

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Fighting rare diseases

A strategic map to fight rare diseases (resulting from a defective gene)… in medicine there are no outliers, no circumstances rare enough to be ignored; every disease, no matter how rare, needs our attention.

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Cell & Gene Therapies

Hundreds of trials are underway with some major therapeutic breakthroughs… Will their use become ubiquitous? Or will its adoption be slow? Here’s a map of the things that matter when discussing CMC issues to develop an advanced therapy.

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